Flavonoids from the Stem Bark of Akway (Drymis beccariana Gibs) and Theirs Antimalarial Properties Tati Herlina1*), Tarso Rudiana 2), Euis Julaeha1), Anni Parubak3)
1)Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran,
Jatinangor 45363, Sumedang, West Java, Indonesia
2)Program Study Chemistry, Faculty of Sciences and Pharmacy, Universitas Mathlaul Anwar,
Jl. Raya Labuan KM 23, Pandeglang, Banten, Indonesia
3)Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negri Papua,
Manokwari, West Papua, Indonesia
Abstract
Akway (Drimys beccariana, Gibbs) is a plant endemic to Papua highlands contained in Manokwari. D. beccariana is used for traditional malaria treatment in West Papua. The methanol extract of the stem bark of D. beccariana demonstrated significant antimalarial activity against Plasmodium falciparum parasites, in vitro. The methanol extract of D. beccariana was dissolved in water and partitioned between n-hexane and ethyl acetate. The ethyl acetate extract was separated through several column chromatography techniques on silica gel, resulting in three known compounds (1-3). The chemical structures of compounds 1-3 were identified based on spectroscopic data and on comparison with data previously reported and identified as 5,3-dihydroxy-7,4-dimethoxyflavone (1), 5,7- dihydroxy -4-methoxyflavone (2), and 5-hydroxy-7,3,4-trimethoxyflavone (3). Compounds 1-3 showed strong antimalarial activity against 3D7 strain of P. falciparum with IC50 values of 0.002, 0.005, and 0.001 mikro Molar, respectively. This result indicates that stem bark of D. beccariana is a promising source of antimalarial agents, and merits further investigation.
